Research progress of silk fibroin-based nanoparticulate drug delivery systems / 药学学报

Silk fibroin is a natural polymer with certain water solubility, structural modification, good biocompatibility and biodegradability, which can be used as a drug delivery carrier material. As a promising drug delivery system, drug-loaded silk fibroin nanoparticles can control drug release, reduce toxicity and improve therapeutic effects. In this paper, the basic characteristics of silk fibroin, the preparation methods of drug-loaded silk fibroin nanoparticles and the application of silk fibroin in nanoparticulate drug delivery systems are reviewed, and on this basis, the further development of drug-loaded silk fibroin nanoparticles is prospected.

Review and Prospect of Drug Solid Dispersion Preparation Technology / 中国药学杂志

Solid dispersions provide an effective technical method for improving solubility and bioavailability of insoluble drugs. From its discovery to the present 60 years, 26 drug formulations have been approved by FDA. Moreover, the preparation technology of solid dispersion system has been continuously innovated and developed, such as electrospinning method, supercritical fluid method, spray freeze-drying technology and so on. In this paper, the development process of solid dispersion technology and carrier is reviewed, and the development of solid dispersion technology and carrier is summarized, and the existing problems are analyzed and prospected. It is expected to provide the reference for the research and development of drug solid dispersion.

Improvement of in vitro dissolution and physical stability for spironolactone solid dispersion formulated with Soluplus / 药学学报

Spironolactone, a class II drug of the biopharmaceutics classification system, has low oral bioavailability due to poor solubility. Spironolactone solid dispersions were prepared using the solvent method in order to improve its aqueous solubility. Optimization studies of spironolactone solid dispersions were performed using in vitro dissolution tests. Differential scanning calorimetry, X-ray diffraction and Fourier transform infrared were used to investigate the physical state of the drug in carrier materials and to detect the possible interactions between the drug and carrier materials in the solid dispersions. In addition, stress tests were employed to elucidate the key factors which have influence on the stability of the spironolactone solid dispersions. Results showed that spironolactone in the solid dispersions formulated with Soluplus and HPMC-E5 were both in amorphous state and the hydrogen bonds between the drug and carrier materials were formed in the solid dispersion. Therefore, the in vitro dissolution of spironolactone was also significantly enhanced. Stress tests demonstrated that the physical stability of spironolactone solid dispersions prepared with Soluplus was greatly improved compared to those formulated with HPMC-E5. Thus, spironolactone solid dispersion formulated with Soluplus using the solvent method could be used to improve the in vitro dissolution and stability of poorly soluble drugs.

Research advances in materials for microspheres as drug delivery system / 中国药科大学学报

@#Microsphere as a drug delivery system with broad prospect for development and application has always been a research focus in pharmaceutics for its. Though literature survey of related papers published in domestic and foreign journals by Chinese authors in 2016, the research advances of materials of microspheres, which can be divided into natural polymer materials, synthetic polymer materials and inorganic materials, were summarized. Microsphere products at home and abroad were also analyzed. This review will provide some reference for correlative researchers.

Applications of immobilization techniques in the screening of active constituents from traditional Chinese medicines / 药学学报

It has been an active approach to screen the active ingredients in traditional Chinese medicines (TCMs) according to the affinity property between small molecule compounds and biomaterials such as cells, bacteria and proteins. On the other hand, the biomaterials can be immobilized on a solid support before the screening procedure. The immobilization method not only can maintain the biological activities of biomaterials, but also have other advantages such as high efficiency, simple operation, easy to be continuous and automatic, etc. Carrier materials (solid supports) for the immobilization including silica gel, magnetic materials, hollow fiber, and the surface plasma resonance sensor chips have been used to immobilize biomaterials and successfully applied in the screening of active ingredients from TCMs. In this paper, applications of immobilization techniques in the screening of active components from TCMs were reviewed to provide a scientific reference to the future applications.

Research progress in nanogel carrier systems / 中国药学杂志

Nanogels combine the advantages of hydrogels and nanoparticles, such as small particle size, prolonged blood circulation time, biocompatibility, biodegradation and high drug loading. Common carrier materials is used for the preparation of nanogels include polyacrylic acid, polyacrylamide, pluronic, polysaccharide and their derivates. They can be cross-linked based on amine reaction, "click" chemistry, photo-induced cross-linking, physical cross-linking or heterogeneous polymerization of monomers to form nanogel carrier systems. Nanogels, as ideal and novel drug delivery systems, have great promise in the delivery of chemotherapeutic drugs, proteins and genes. The carrier materials, preparation methods and applications of nanogels were reviewed based on relevant articles published in recent years.

Advances in targeting nano drug therapy and its carrier of colorectal cancer / 国际外科学杂志

Colorectal cancer is currently the world's fourth incidence of malignant tumors,the early clinical manifestations are not obvious,so the early diagnosis is difficult to find,most of them are in progress.Treatment of advanced stage with chemotherapy,interventional therapy,radiotherapy and other methods,in which chemotherapy in the killing of tumor cells at the same time,the normal cells of the body also has a killing effect.In recent years,all kinds of new nano targeting delivery system has been developed,which can be targeted to the tumor tissue,so it is more and more important in the treatment of intestinal tumor,especially with metastasis.The author has made an overview of the types of nano drug carrier materials,the research status and its application in the research of colorectal cancer.

Preparation and Study of Acanthopanax Leaves Total Flavonoids Solid Dispersions In Vitro / 世界科学技术-中医药现代化

This study was aimed to prepare solid dispersions of Acanthopanax leaves total flavonoids in order to im-prove its bioavailability. PEG4000, PEG6000, F68, PVPK30 were used as carrier materials in the preparation of four different types of solid dispersion to screen the best type of carrier material and evaluate the amount of carrier mate-rial and its influence on the drug dissolution. Rutin was used as reference substance. NaNO2-Al(NO3)3-NaOH was used as the color system, with a UV spectrophotometer measured absorbance at 500 nm. The dissolution characteris-tics of different proportions of solid dispersions were examined in vitro. The results showed that compared with raw material, the in vitro drug release rate with PVPK30 as carrier material in the obtained solid dispersion of the pro-portion of the raw material was significantly improved, and the cumulative release rate was also increased significant-ly. It was concluded that the solid dispersion prepared by solvent method significantly improved in vitro drug release in water.

Advances in the research of carrier materials for implant drug delivery system within bone / 国际生物医学工程杂志

Implant drug delivery system(IDDS) is helpful to the therapy of infection、tuberculosis and tumor of bone. With the development of tissue engineering, various materials has been used as the carriers for the IDDS. Research of the carrier materials used in implant drug delivery system is reviewed in this article.